| Name | Image | Role | Notes |
|---|---|---|---|
| Benedict Cumberbatch |  |
Dr. Stephen Strange | |
| Chiwetel Ejiofor |  |
Karl Mordo | |
| Rachel McAdams |  |
Dr. Christine Palmer | |
| Benedict Wong |  |
Wong | |
| Mads Mikkelsen |  |
Kaecilius | |
| Tilda Swinton |  |
The Ancient One | |
| Michael Stuhlbarg |  |
Dr. Nicodemus West | |
| Benjamin Bratt |  |
Jonathan Pangborn | |
| Scott Adkins |  |
Lucian / Strong Zealot | |
| Zara Phythian |  |
Brunette Zealot | |
| Alaa Safi |  |
Tall Zealot | |
| Katrina Durden | Blonde Zealot | ||
| Topo Wresniwiro |  |
Hamir | |
| Umit Ulgen | Sol Rama | ||
| Linda Louise Duan |  |
Tina Minoru | |
| Mark Anthony Brighton |  |
Daniel Drumm | |
| Meera Syal | Dr. Patel | ||
| Amy Landecker | Dr. Bruner | ||
| Adam Pelta-Pauls | Nurse Billy | ||
| Sarah Malin | Dr. Garrison | ||
| Eben Young | Dr. Weiss | ||
| Kobna Holdbrook-Smith | Physical Therapist | ||
| Elizabeth Healey | Concerned Doctor | ||
| Guillaume Faure | Reluctant Surgeon | ||
| Daniel Dow | Mugger | ||
| Ezra Khan | Kamar-Taj Librarian | ||
| Kimberly Van Luin | Bullet Patient's Wife | ||
| Pat Kiernan | Himself | ||
| Chris Hemsworth |  |
Thor (uncredited) | |
| Stan Lee | Man on Bus (uncredited) |
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Doctor Strange
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