| Year | Title | Image | Role | Notes |
|---|---|---|---|---|
| 1996 | The Substance of Fire |  |
Nurse | Film |
| 1996 | NYPD Blue | Woman | TV Series 1 Episode | |
| 1996 | New York Undercover | Mrs. Stapleton | TV Series, 1 Episode | |
| 1996 | Seven Guitars | Vera | Play
Awards:  | |
| 1998 | The Pentagon Wars | Sgt. Fanning | TV Movie | |
| 1998 | Out of Sight |  |
Moselle | Film |
| 1998 | Grace & Glorie | Rosemary Allbright | TV Movie | |
| 1998 | Miss Apprehension and Squirt | Sharon Hughes | Film | |
| 2000 | Judging Amy | Celeste | TV Series, 1 Episode | |
| 2000 | Traffic | Social Worker | Film | |
| 2000 | City of Angels | Nurse Lynnette Peeler | TV Series, 24 Episodes | |
| 2001 | Amy & Isabelle | Dottie | Film | |
| 2001 | The Shrink Is In | Robin | Film | |
| 2001 | Providence | Dr. Eleanor Weiss | TV Series, 1 Episode | |
| 2001 | The Guardian | Suzanna Clemons' Attorney | TV Series, 1 Episode | |
| 2001 | Third Watch | Margo Rodriguez | TV Series, 1 Episode | |
| 2001 | Kate & Leopold | Policewoman | Film | |
| 2001 | King Hedley II | Tonya | Play
Awards:  | |
| 2002 | Law & Order: Criminal Intent |  |
Terry Randolph | TV Series, 1 Episode |
| 2002 | The Division | Dr. Georgia Davis | TV Series, 1 Episode | |
| 2002 | Far from Heaven | Cybil | Film | |
| 2002 | Antwone Fisher | Eva May | Film | |
| 2002 | CSI: Crime Scene Investigation | Attorney Campbell | TV Series, 1 Episode | |
| 2002 | Solaris | Gordon | Film | |
| 2002 | Father Lefty | TV Movie | ||
| 2003 | Hack | Stevie Morgan | TV Series, 1 Episode | |
| 2003 | The Practice | Aisha Crenshaw | TV Series, 1 Episode | |
| 2003-2008 | Law & Order: Special Victims Unit |  |
Donna Emmett | TV Series, 7 Episodes |
| 2004 | Century City | Hannah Crane | TV Series, 9 Episodes | |
| 2005 | Jesse Stone: Stone Cold | Molly Crane | TV Movie | |
| 2005 | Threshold | Victoria Rossi | TV Series, 1 Episode | |
| 2005 | Get Rich or Die Tryin' | Grandma | Film | |
| 2005 | Syriana | CIA Chairwoman (uncredited) | Film | |
| 2006 | Jesse Stone: Night Passage | Molly Crane | TV Movie | |
| 2006 | The Architect | Tonya Neely | Film | |
| 2006 | Jesse Stone: Death in Paradise | Molly Crane | TV Movie | |
| 2006 | Without a Trace | Audrey Williams | TV Series, 1 Episode | |
| 2006 | World Trade Center | Mother in Hospital | Film | |
| 2006 | Life Is Not a Fairytale: The Fantasia Barrino Story | Diane Barrino | TV Movie | |
| 2007 | Disturbia |  |
Detective Parker | Film |
| 2007 | Jesse Stone: Sea Change | Molly Crane | TV Movie | |
| 2007 | Traveler | Agent Jan Marlow | TV Series, 8 Episodes | |
| 2007 | Fort Pit | TV Movie | ||
| 2008 | The Andromeda Strain | Dr. Charlene Barton | TV Series, 3 Episodes | |
| 2008 | Brothers & Sisters | Ellen Snyder | TV Series, 1 Episode | |
| 2008 | Nights in Rodanthe | Jean | Film | |
| 2008 | Doubt |  |
Mrs. Miller | Film Awards:
 |
| 2009 | Madea Goes to Jail | Ellen | Film | |
| 2009 | State of Play | Dr. Judith Franklin | Film | |
| 2009 | Law Abiding Citizen |  |
Mayor | Film |
| 2010 | United States of Tara | Lynda P. Frazier | TV Series, 6 Episodes | |
| 2010 | Knight and Day |  |
Director George | Film |
| 2010 | Eat Pray Love |  |
Delia Shiraz | Film |
| 2010 | Trust |  |
Gail Friedman | Film |
| 2010 | It's Kind of a Funny Story |  |
Dr. Eden Minerva | Film |
| 2010 | Fences | Rose Maxson | Play
Awards: | |
| 2011 | The Help |  |
Aibileen Clark | Film Awards:
|
| 2011 | Touch of Evil | The Vengeful Caretaker | Short | |
| 2011 | Extremely Loud & Incredibly Close | Abby Black | Film | |
| 2012 | Won't Back Down | Nona Alberts | Film | |
| 2013 | Beautiful Creatures |  |
Amma | Film |
| 2013 | Sofia the First |  |
Helen Hanshaw | TV Series, 1 Episode |
| 2013 | Prisoners |  |
Nancy Birch | Film |
| 2013 | Ender's Game |  |
Major Gwen Anderson | Film |
| 2013 | The Disappearance of Eleanor Rigby: Him | Professor Lillian Friedman | Film | |
| 2013 | The Disappearance of Eleanor Rigby: Her | Professor Lillian Friedman | Film | |
| 2014 | The Disappearance of Eleanor Rigby: Them | Professor Lillian Friedman | Film | |
| 2014 | Get on Up |  |
Susie Brown | Film |
| 2014-2019 | How to Get Away with Murder |  |
Annalise Keating | TV Series, 69 Episodes Awards:
|
| 2015 | Blackhat |  |
Carol Barrett | Film |
| 2015 | Lila & Eve |  |
Lila | Film |
| 2016 | Custody |  |
Martha Schulman | Film |
| 2016 | Suicide Squad |  |
Amanda Waller | Film |
| 2016 | Fences |  |
Rose Maxson | Film Awards:
 |
| 2017 | American Koko | Narrator | TV Series, 12 Episodes | |
| 2018 | Scandal | Annalise Keating | TV Series, 1 Episode | |
| 2018 | Widows | Veronica | Film | |
| 2019 | Troop Zero | Film | ||
| TBA | Untitled Harriet Tubman Project | Harriet Tubman | Film |
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Viola Davis
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